Characteristics of sebaceous carcinoma and early outcomes of treatment using Mohs micrographic surgery versus wide local excision: an update of the Mayo Clinic experience over the past 2 decades.
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| Abstract | BACKGROUND: OBJECTIVE: To characterize SC and treatment approaches and outcomes. METHODS AND MATERIALS: We retrospectively reviewed records of patients with SC from 1992 through 2012. Recurrence-free survival was estimated and compared between groups. RESULTS: We identified 52 patients with SC (39, 75.0% male). Mean age ± standard deviation at diagnosis was 72.7 ± 10.8. Forty-nine patients (94.2%) were white. Twenty-one (of 29 with known status) had a diagnosis of Muir-Torre syndrome. Six had multiple primary SCs (total of 73 SCs in 52 patients). The most common locations for SC were the back (20.5%), cheek (13.7%), nose (11.0%), and eye (9.6%). Treatment was recorded for 70 SCs; 35 (50.0%) were treated using Mohs micrographic surgery (MMS) and 26 (37.1%) using wide local excision (WLE). Of the 45 patients (66 SCs) with clinical follow-up, three (6.7% of patients; 4.8% of SCs) had documented recurrence. CONCLUSION: MMS and WLE are effective treatments for SC. Further research is warranted to determine whether one treatment is more efficacious than the other.
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| Authors | Jennifer L Hou, Jill M Killian, Christian L Baum, Clark C Otley, Randall K Roenigk, Christopher J Arpey, Amy L Weaver, Jerry D Brewer |
| Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 40 Issue 3 Pg. 241-6 (Mar 2014) ISSN: 1524-4725 [Electronic] United States |
| PMID | 24460730 (Publication Type: Journal Article) |
| Copyright | © 2014 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc. |
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