Outcomes of operative sperm retrieval strategies for fertility preservation among males scheduled to undergo cancer treatment.

Abstract

OBJECTIVE:

To describe the outcomes of electroejaculation (EEJ) and testicular sperm extraction (TESE) performed for fertility preservation among male patients who are unable to ejaculate or have nonobstructive azoospermia/severe oligospermia before definitive cancer therapy.

DESIGN:

Retrospective cohort study.

SETTING:

Tertiary cancer referral center.

PATIENT(S):

Forty-nine patients seeking fertility preservation before definitive cancer therapy, with anejaculation, religious or cultural objections to masturbation, azoospermia, or severe oligospermia requiring either EEJ or TESE.

INTERVENTION(S):

EEJ and TESE.

MAIN OUTCOME MEASURE(S):

Sperm retrieval rates.

RESULT(S):

Fifty-nine percent of patients overall and 60% of adolescents/young adults had sperm retrieved for cryopreservation. EEJ was successful in retrieving sperm in 60% of adolescents. Of all adolescents and young adults undergoing TESE, 33% had sperm retrieved for cryopreservation. No complications were reported. Chemotherapy was commenced without delay in all patients requiring it, frequently on the same day as the sperm retrieval.

CONCLUSION(S):

EEJ and TESE can be safely and successfully used for fertility preservation before cancer therapy among boys and young adult men who are unable to provide a semen specimen or have nonobstructive azoospermia, and they should be considered in all men meeting this patient profile.

• Authors: Boback M Berookhim, John P Mulhall
• Journal: Fertility and sterility (Fertil Steril) Vol. 101 Issue 3 Pg. 805-11 (Mar 2014) ISSN: 1556-5653 [Electronic] United States
• PMID: 24424372 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Chemical References

• Antineoplastic Agents

Topics

• Adolescent
• Adult
• Antineoplastic Agents (adverse effects)
• Antineoplastic Protocols
• Child
• Cohort Studies
• Ejaculation (drug effects, physiology)
• Fertility Preservation (methods)
• Humans
• Male
• Middle Aged
• Neoplasms (diagnosis, therapy)
• Retrospective Studies
• Sperm Retrieval
• Treatment Outcome
• Young Adult