Prognostic value of the proliferation marker Ki-67 in laryngeal carcinoma: results of the accelerated radiotherapy with carbogen breathing and nicotinamide phase III randomized trial.

Abstract

BACKGROUND:

The prognostic and predictive value of the proliferation marker Ki-67 was investigated in a randomized trial comparing accelerated radiotherapy with carbogen breathing and nicotinamide (ARCON) to accelerated radiotherapy in laryngeal carcinoma.

METHODS:

Labeling index of Ki-67 (Li Ki-67) in immunohistochemically stained biopsies and the colocalization with carbonic anhydrase IX (CAIX) were related to tumor control and patient survival.

RESULTS:

On average, node-positive patients had a higher Li Ki-67 (median 14% vs 8%; p < .01). In patients with a high Li Ki-67, the 5-year regional control and metastases-free survival were 79% versus 96% (p < .01) and 71% versus 88% (p = .05) for accelerated radiotherapy and ARCON, respectively. The 5-year local control and disease-specific survival were not significantly different. Patients with low Ki-67 expression had an excellent outcome with accelerated radiotherapy alone.

CONCLUSION:

Patients with laryngeal carcinomas with high proliferative activity are at increased risk of regional and distant metastases formation. This risk can be reduced by treatment with ARCON.

• Authors: Saskia E Rademakers, Ilse J Hoogsteen, Paul F Rijken, Chris H Terhaard, Patricia A Doornaert, Johannes A Langendijk, Piet van den Ende, Albert J van der Kogel, Johan Bussink, Johannes H Kaanders
• Journal: Head & neck (Head Neck) Vol. 37 Issue 2 Pg. 171-6 (Feb 2015) ISSN: 1097-0347 [Electronic] United States
• PMID: 24347430 (Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 Wiley Periodicals, Inc.

Chemical References

• Antigens, Neoplasm
• Ki-67 Antigen
• Radiation-Sensitizing Agents
• Vitamin B Complex
• Carbon Dioxide
• Niacinamide
• carbogen
• CA9 protein, human
• Carbonic Anhydrase IX
• Carbonic Anhydrases
• Oxygen

Topics

• Administration, Inhalation
• Adult
• Aged
• Aged, 80 and over
• Antigens, Neoplasm (metabolism)
• Carbon Dioxide (therapeutic use)
• Carbonic Anhydrase IX
• Carbonic Anhydrases (metabolism)
• Carcinoma, Squamous Cell (metabolism, pathology, radiotherapy)
• Female
• Humans
• Immunohistochemistry
• Ki-67 Antigen (metabolism)
• Laryngeal Neoplasms (metabolism, pathology, radiotherapy)
• Male
• Middle Aged
• Neoplasm Metastasis
• Niacinamide (therapeutic use)
• Oxygen (therapeutic use)
• Prognosis
• Radiation-Sensitizing Agents (therapeutic use)
• Vitamin B Complex (therapeutic use)