Abstract |
Extranodal natural killer (NK)/ T-cell lymphoma (ENKL) is an aggressive neoplasm with poor prognosis. Currently, there is no consensus on the optimal treatment of this disease. In this study, we report the efficacy of a pegaspargase (PEG-Asp)-based chemotherapy, a DDGP regimen (PEG-Asp, dexamethasone, cisplatin, gemcitabine), for the treatment of newly-diagnosed ENKL. From August 2010 to May 2012, 12 patients with newly-diagnosed stage II - IV ENKL were initially treated with a DDGP regimen in our center. Ten patients (10/12, 83.3%) achieved complete response (CR) and two (2/12, 16.7%) achieved partial response (PR). The objective overall response rate (ORR) was 100%. Three patients (3/12, 25.0%) relapsed, and as a result, two died of disease. Eight patients (8/12, 66.7%) were alive with no evidence of disease (NOD) after a median follow-up of 19 months (range 16 - 31 months). Hematologic toxicity was the most frequent toxicity reported in this study. Grade 3/4 leukopenia and neutropenia were common and both occurred in eight patients (8/12, 66.7%), respectively. Additionally, six patients (6/12, 50.0%) experienced grade 3/4 thrombocytopenia and three (3/12, 25.0%) experienced grade 3/4 anemia. However, no patient died of hematologic toxicity. Our results demonstrate the significant efficacy and safety profile of a DDGP regimen in the treatment of newly-diagnosed ENKL, and indicate the potential of this regimen as a first-line therapy against this disease.
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Authors | L Li, C Zhang, L Zhang, X Li, J J Wu, Z C Sun, X R Fu, X H Wang, Y Chang, R Wang, Y J Qiu, M Z Zhang |
Journal | Neoplasma
(Neoplasma)
Vol. 61
Issue 2
Pg. 225-32
( 2014)
ISSN: 0028-2685 [Print] Slovakia |
PMID | 24299319
(Publication Type: Journal Article)
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Chemical References |
- Deoxycytidine
- Polyethylene Glycols
- pegaspargase
- Dexamethasone
- Asparaginase
- Cisplatin
- Gemcitabine
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Asparaginase
(administration & dosage, adverse effects)
- Cisplatin
(administration & dosage)
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Dexamethasone
(administration & dosage)
- Drug-Related Side Effects and Adverse Reactions
(classification, pathology)
- Female
- Humans
- Lymphoma, Extranodal NK-T-Cell
(drug therapy, pathology)
- Male
- Middle Aged
- Polyethylene Glycols
(administration & dosage, adverse effects)
- Remission Induction
- Gemcitabine
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