GM-CSF administration augments the survival of ity-resistant A/J mice, but not ity-susceptible C57BL/6 mice, to a lethal challenge with Salmonella typhimurium.

Abstract

Ity resistant A/J mice were challenged with a lethal dose (2 x 10(3) organisms) of Salmonella typhimurium. Infected mice treated with 1 microgram of GM-CSF twice daily showed increased median survival time and had a higher survival fraction than untreated controls. GM-CSF was most effective when given for a brief period (1 to 2 days) after infection. Pretreatment of the mice or delayed treatment with GM-CSF had no effect on the survival of the mice. Studies on the effect of GM-CSF on the bacterial load showed that mice treated with GM-CSF had fewer S. typhimurium in the spleen and peritoneal cavity on day 4 but not on day 2 after infection. GM-CSF treatment of ity-susceptible C57BL/6 mice infected with 10 organisms had no therapeutic effect.

• Authors: P J Morrissey, K Charrier
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 144 Issue 2 Pg. 557-61 (Jan 15 1990) ISSN: 0022-1767 [Print] United States
• PMID: 2404067 (Publication Type: Journal Article)

Chemical References

• Colony-Stimulating Factors
• Growth Substances
• Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• Animals
• Colony-Stimulating Factors (therapeutic use)
• Granulocyte-Macrophage Colony-Stimulating Factor
• Growth Substances (therapeutic use)
• Mice
• Mice, Inbred A (immunology)
• Mice, Inbred C57BL (immunology)
• Peritoneal Cavity (microbiology)
• Salmonella Infections, Animal (genetics, immunology, microbiology)
• Spleen (microbiology)
• Survival Analysis