Abstract | BACKGROUND: METHODS: A total of 162 IP specimens were collected from 147 patients treated at the University of Michigan between 1996 and 2011. Twenty-two specimens contained carcinoma. Tumor was extracted for construction of 2 tissue microarrays and stained for p16, EGFR, p53, and cyclin D1. Tumor staining intensity and percentage staining were scored. RESULTS: Benign disease was positive for p16 in 64%, EGFR in 50%, p53 in 30%, and cyclin D1 in 76%. IP with carcinomatous degeneration was positive for p16 in 14%, EGFR in 71%, p53 in 62%, and cyclin D1 in 76%. The differences in staining positivity between benign and malignant disease reached significance for p16 and p53 only. Mean percentage staining by tumor surface area for IP and IP with carcinoma was 12% vs 7% for p16 (no statistical significance [NS]), 20% vs 34% for EGFR (NS), 4% vs 24% for p53 (p < 0.001), and 17% vs 21% for cyclin D1 (NS). CONCLUSION: Important characteristic staining pattern for IP with and without carcinoma are highlighted in this study. Unlike recent trends in human papilloma virus (HPV)-related head and neck malignancies, low expression of p16 is a marker for malignancy in this series. Positive staining for p53 correlates with the development of carcinoma in IP.
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Authors | Giant C Lin, Adam Scheel, Sarah Akkina, Steven Chinn, Martin Graham, Christine Komarck, Heather Walline, Jonathan B McHugh, Mark E Prince, Thomas E Carey, Mark A Zacharek |
Journal | International forum of allergy & rhinology
(Int Forum Allergy Rhinol)
Vol. 3
Issue 11
Pg. 885-9
(Nov 2013)
ISSN: 2042-6984 [Electronic] United States |
PMID | 24039221
(Publication Type: Journal Article)
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Copyright | © 2013 ARS-AAOA, LLC. |
Chemical References |
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Topics |
- Cyclin D1
(analysis)
- ErbB Receptors
(analysis)
- Genes, p16
- Genes, p53
- Humans
- Papilloma, Inverted
(pathology)
- Paranasal Sinus Neoplasms
(pathology)
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