Marrow mesenchymal stromal cells reduce methicillin-resistant Staphylococcus aureus infection in rat models.

Abstract

BACKGROUND AIMS:

Staphylococci account for a large proportion of hospital-acquired infections, especially among patients with indwelling devices. These infections are often caused by biofilm-producing strains, which are difficult to eradicate and may eventually cause bacteremia and metastatic infections. Recent evidence suggests that mesenchymal stem cells can enhance bacterial clearance in vivo.

METHODS:

In this study, a rat model with carboxymethyl cellulose pouch infection was used to analyze the efficacy of bone marrow-derived mesenchymal stromal cells (BMSCs) against the methicillin-resistant Staphylococcus aureus.

RESULTS:

The results showed that the administration of BMSCs effectively reduced the number of bacterial colonies and the expression of many cytokines and chemokines (such as interleukin [IL]-6, IL-1β, IL-10 and CCL5). Unlike the fibroblast control groups, the pouch tissues from the BMSC-treated rats showed the formation of granulations, suggesting that the healing of the wound was in progress.

CONCLUSIONS:

The results indicate that the treatment of BMSCs can reduce methicillin-resistant S aureus infection in vivo, thereby reducing the inflammatory response.

• Authors: Yuan Yuan, Songyi Lin, Na Guo, Chengcheng Zhao, Suxia Shen, Xiujuan Bu, Haiqing Ye
• Journal: Cytotherapy (Cytotherapy) Vol. 16 Issue 1 Pg. 56-63 (Jan 2014) ISSN: 1477-2566 [Electronic] England
• PMID: 23993644 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Chemical References

• Carboxymethylcellulose Sodium

Topics

• Animals
• Bone Marrow Cells (cytology, metabolism)
• Carboxymethylcellulose Sodium (toxicity)
• Cell- and Tissue-Based Therapy
• Disease Models, Animal
• Humans
• Mesenchymal Stem Cell Transplantation
• Mesenchymal Stem Cells (cytology, metabolism)
• Methicillin-Resistant Staphylococcus aureus (drug effects, pathogenicity)
• Rats
• Staphylococcal Infections (chemically induced, microbiology, pathology, therapy)