Abstract | IMPORTANCE: OBSERVATIONS: A report of a single case of a 53-year-old man with myasthenia gravis and a prior thymectomy presenting with 2 months of diffuse, involuntary muscle twitching in the absence of myasthenic symptoms, electrophysiologically confirmed to be neuromyotonia. Further evaluation revealed the recurrence of malignant thymoma, accompanied by refractory arrhythmia. Serologic and cerebrospinal fluid testing confirmed the presence of antibodies directed against 2 voltage-gated potassium channel–associated proteins: LGI1 and Caspr2. CONCLUSIONS AND RELEVANCE: This case highlights the overlap of myasthenia, neuromyotonia, and thymoma, emphasizing the importance of appropriate tumor screening in the presence of either of the former 2 conditions.
|
Authors | Jori Fleisher, Megan Richie, Raymond Price, Steven Scherer, Josep Dalmau, Eric Lancaster |
Journal | JAMA neurology
(JAMA Neurol)
Vol. 70
Issue 10
Pg. 1311-4
(Oct 2013)
ISSN: 2168-6157 [Electronic] United States |
PMID | 23978943
(Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Autoantibodies
- Potassium Channels, Voltage-Gated
|
Topics |
- Autoantibodies
(metabolism)
- Humans
- Isaacs Syndrome
(complications, diagnosis, metabolism)
- Male
- Middle Aged
- Myasthenia Gravis
(diagnosis, etiology, immunology, metabolism)
- Potassium Channels, Voltage-Gated
(immunology)
- Tomography, X-Ray Computed
|