Is 1,4-dioxane a genotoxic carcinogen?

Abstract

Female Sprague-Dawley rats were given 0, 168, 840, 2550 or 4200 mg/kg of 1,4-dioxane 21 and 4 h before sacrifice. Hepatic DNA damage (by the alkaline elution technique), ornithine decarboxylase activity (ODC), reduced glutathione content, cytochrome P-450 content and serum alanine aminotransferase activity (ALT) were determined. Treatment with 1,4-dioxane increased hepatic DNA damage and cytochrome P-450 content at doses of 2550 and 4200 mg/kg. Large increases in the activity of hepatic ODC were observed at 840, 2550 and 4200 mg/kg of 1,4-dioxane. Thus the data suggest that 1,4-dioxane is a weak genotoxic carcinogen in addition to being a strong promoter of carcinogenesis (a non-genotoxic carcinogen).

• Authors: K T Kitchin, J L Brown
• Journal: Cancer letters (Cancer Lett) Vol. 53 Issue 1 Pg. 67-71 (Aug 1990) ISSN: 0304-3835 [Print] Ireland
• PMID: 2397485 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Carcinogens
• Dioxanes
• Dioxins
• DNA
• 1,4-dioxane

Topics

• Animals
• Carcinogens (toxicity)
• DNA (drug effects)
• DNA Damage
• Dioxanes (toxicity)
• Dioxins (toxicity)
• Dose-Response Relationship, Drug
• Female
• Genes (drug effects)
• Liver (drug effects)
• Rats
• Rats, Inbred Strains