Vaginal myofibroblastoma with prostatic glands: is there an association with tamoxifen use? A case report.

Abstract

BACKGROUND:

Both ectopic prostate tissue in the female genital tract and vaginal myofibroblastoma have rarely been reported in the literature. Tamoxifen use has been associated with the development of vaginal myofibroblastoma.

CASE:

A 76-year-old, multiparous woman who had taken tamoxifen for breast cancer presented with postmenopausal bleeding and a vaginal mass. Endometrial work-up revealed a benign polyp, and the polypoid tumor in the vagina was found to be a myofibroblastoma harboring ectopic prostatic glands.

CONCLUSION:

To our knowledge this is the first case of these two rare pathologic entities occurring together. Of note, this patient also had a history of tamoxifen therapy, like some of the previous patients with vaginal myofibroblastoma.

• Authors: Ellen Lorange, Oz Harmanli, Q Jackie Cao, Keisha A Jones
• Journal: The Journal of reproductive medicine (J Reprod Med) 2013 Jul-Aug Vol. 58 Issue 7-8 Pg. 344-6 ISSN: 0024-7758 [Print] United States
• PMID: 23947086 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Tamoxifen

Topics

• Aged
• Antineoplastic Agents, Hormonal (adverse effects)
• Breast Neoplasms (drug therapy)
• Choristoma (pathology)
• Female
• Humans
• Male
• Neoplasms, Muscle Tissue (pathology)
• Prostate
• Tamoxifen (adverse effects)
• Vaginal Neoplasms (pathology)