Concomitant autoantibodies in newly diagnosed diabetic children with transient celiac serology or proven celiac disease.

Abstract

BACKGROUND:

We previously demonstrated that children with Type 1 Diabetes Mellitus (T1DM) may have transiently elevated tissue transglutaminase antibodies (TTG) on a gluten-containing diet. This study aimed to examine if the presence of autoantibodies in newly diagnosed T1DM differs between patients with celiac disease and those with transient celiac serology.

METHODS:

Forty children were identified who had been diagnosed with T1DM between 2003 and 2009 and who had elevated serum IgA-TTG antibody levels at diagnosis. Blood samples were collected for measurement of insulin (IA-2A) antibodies, islet cell antigen (ICA) antibodies, glutamic acid decarboxylase (GAD) antibodies, thyroglobulin (TgAb) antibodies, and thyroid peroxidase (TPO) antibodies. Children diagnosed with celiac disease (CD; group 1, n=23) and children in whom TTG antibody levels spontaneously normalized over time (group 2, n=17) were compared.

RESULTS:

No significant differences in positivity rates between groups 1 and 2 were found for any of the autoantibodies tested. The respective findings were as follows: IA-2A 50% and 47.1% (p=0.855); ICA 77.3% and 76.5% (p=0.953); GAD 27.3% and 52.9% (p=0.102). Thyroid antibodies were found positive in a limited number of patients: TgAb 4.5% and 11.8%; TPO 4.5% and 11.8%. In addition, antibody titer levels did not differ significantly for all autoantibodies. Difference in occurrence of clinical or subclinical thyroid disease did not reach significance (4.3% vs. 29.4%; p=0.07). Age was positively correlated with the presence of thyroglobulin and thyroid peroxidase antibodies, and negatively correlated with the presence of insulin antibody.

CONCLUSION:

Neither the number of concomitant autoantibodies nor their titers in newly diagnosed T1DM differed between patients with proven CD and those with transient TTG serology.

• Authors: Iva Hojsak, Noam Zevit, Orith Waisbourd-Zinman, Yoram Rosenbach, Yael Mozer-Glassberg, Shlomit Shalitin, Moshe Phillip, Raanan Shamir
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 26 Issue 11-12 Pg. 1099-104 ( 2013) ISSN: 2191-0251 [Electronic] Germany
• PMID: 23817597 (Publication Type: Journal Article)

Chemical References

• Autoantibodies

Topics

• Autoantibodies (immunology)
• Celiac Disease (complications, immunology)
• Child
• Diabetes Mellitus, Type 1 (complications, immunology)
• Humans