Tumorigenicity of nickel subsulfide in Strain A/J mice.

Abstract

The pulmonary tumor response of Strain A mice has been reported to be a rapid and efficient predictor of carcinogenic potential for a variety of chemicals. The route of exposure has usually been by intraperitoneal injection (i.p.) of solubilized materials. We compared intratracheal (i.t.) instillation as a more representative route typical of human exposures, with i.p. injection of nickel subsulfide, a potent animal carcinogen. Animals were sacrificed either 20 weeks after the first dosing, or were held until 45 weeks after the first dosing. Urethane, a positive control, produced a significant increase in pulmonary tumor response after i.t. instillation as well as i.p. injection. For nickel subsulfide treated animals, there was no evidence of a dose-related increase in pulmonary tumor response in any i.p. or i.t. treatment group when compared with age-matched controls.

• Authors: D A McNeill, C E Chrisp, G L Fisher
• Journal: Drug and chemical toxicology (Drug Chem Toxicol) Vol. 13 Issue 1 Pg. 71-86 ( 1990) ISSN: 0148-0545 [Print] United States
• PMID: 2379474 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Urethane
• Nickel
• nickel subsulfide

Topics

• Adenoma (chemically induced, pathology)
• Administration, Inhalation
• Animals
• Carcinogens
• Injections, Intraperitoneal
• Lung Neoplasms (chemically induced, pathology)
• Male
• Mice
• Mice, Inbred A
• Nickel (toxicity)
• Particle Size
• Urethane (toxicity)