Abstract | OBJECTIVE: METHOD: RESULT: SSNI model rats showed significant improvement in mechanical withdrawal threshold and cold pain sensitivity, significant decrease in intracerebral NE and notable increase in DA, 5-HT and their metabolites. Compared with the model group, the sinomenine high dose group showed significant increase in mechanical withdrawal threshold at 60, 90, 180 and 240 min after abdominal administration (P < 0.01), significant decrease in cold pain sensitivity score during 30-240 min (P < 0.05). Sinomenine can significantly up-regulated NE content in striatal extracellular fluid during 45-135 min (P < 0.05), remarkably reduce DA content and DOPAC at 45, 75 and 135 min (P < 0.05), 5-HT content during 45-135 min, DOPAC during 75-165 min (P < 0.05), and 5-HIAA during 45-135 min (P < 0.05). CONCLUSION:
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Authors | Mei-Yu Zhang, Peng Li, Dan-Qiao Wang, Xiao-Hong Niu, Ye Wang, Zhi-Guo Wang, Ying Zhang, Shi Xu, Xiao-Jun Xu |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 38
Issue 4
Pg. 597-604
(Feb 2013)
ISSN: 1001-5302 [Print] China |
PMID | 23713290
(Publication Type: Journal Article)
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Chemical References |
- Analgesics
- Biogenic Monoamines
- Morphinans
- Neurotransmitter Agents
- sinomenine
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Topics |
- Analgesics
(pharmacology)
- Animals
- Biogenic Monoamines
(metabolism)
- Disease Models, Animal
- Extracellular Fluid
(drug effects)
- Male
- Morphinans
(pharmacology)
- Neostriatum
(pathology)
- Neurotransmitter Agents
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Sciatic Nerve
(drug effects, injuries, metabolism, pathology)
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