Abstract | BACKGROUND: Recent research has suggested that the Th1 and Th2 chemokine/ cytokine axis contributes to the development of chronic hypersensitivity pneumonitis (HP). Acute exacerbations (AE) are significant factors in the prognosis of chronic HP. Little is known, however, about these biomarkers in association with AE in chronic HP patients. METHODS: RESULTS: Serum CCL17 levels at baseline independently predicted the first episode of AE (HR, 72.0; 95% CI, 5.03-1030.23; p = 0.002). AE was significantly more frequent in the higher-CCL17 group (≥285 pg/ml) than in the lower-CCL17 group (<285 pg/ml) (log-rank test, p = 0.0006; 1-year incidence: higher CCL17 vs. lower CCL17, 14.3% vs. 0.0%). Serum CCL17 levels and CCR4-positive cells during episodes of AE were increased from the baseline (p = 0.01 and 0.031). CONCLUSIONS: Higher serum concentrations of CCL17 at baseline may be predictive of AE in patients with chronic HP, and CCL17 may contribute to the pathology of AE by inducing the accumulation of CCR4-positive lymphocytes in the lungs.
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Authors | Yasunari Miyazaki, Koji Unoura, Tomoya Tateishi, Takumi Akashi, Tamiko Takemura, Makoto Tomita, Naohiko Inase, Yasuyuki Yoshizawa |
Journal | Respiratory research
(Respir Res)
Vol. 14
Pg. 57
(May 25 2013)
ISSN: 1465-993X [Electronic] England |
PMID | 23705860
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- CCL17 protein, human
- Chemokine CCL17
- Cytokines
- Receptors, CCR4
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Alveolitis, Extrinsic Allergic
(blood, diagnosis, pathology)
- Biomarkers
(blood)
- Bronchoalveolar Lavage Fluid
- Cell Count
- Chemokine CCL17
(blood)
- Chronic Disease
- Cytokines
(blood)
- Female
- Humans
- Lung
(pathology)
- Male
- Middle Aged
- Predictive Value of Tests
- Receptors, CCR4
(biosynthesis)
- Th1-Th2 Balance
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