Abstract | OBJECTIVE: DESIGN: Randomized clinical trial. Animals-211 client-owned cats. PROCEDURES: Cats with ≥ 5 fleas evaluated at 8 veterinary clinics were allocated to receive spinosad (50 to 100 mg/kg [22.7 to 45.5 mg/lb], PO; n = 139) or selamectin (≥ 6 mg/kg [≥ 2.7 mg/lb], topically; 72) once per month. Flea comb counts and FAD scores were determined on day -1, between days 27 and 33, and between days 85 and 95 (evaluations 1, 2, and 3, respectively); day 0 was the first day of drug administration. RESULTS: The most common adverse event was vomiting (14.3% and 2.4% of spinosad- and selamectin-treated cats, respectively). Evaluation 2 and 3 geometric mean flea counts for spinosad-treated cats were significantly lower than those for selamectin-treated cats. Percentage reductions in flea counts for the spinosad and selamectin groups were 97.5% and 88.8% (evaluation 2) and 99.3% and 97.7% (evaluation 3), respectively. At evaluations 2 and 3, 70.6% and 92.6% of spinosad-treated cats and 29.4% and 64.7% of selamectin-treated cats were free of fleas, respectively. Weighted FAD scores for spinosad- and selamectin-treated cats decreased 94.2% and 80.0% during the study, respectively. Spinosad tablets were successfully administered during 98.1% of treatments. CONCLUSIONS AND CLINICAL RELEVANCE:
|
Authors | Tandy E Paarlberg, Scott Wiseman, Candace M Trout, Elizabeth A Kee, Daniel E Snyder |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 242
Issue 8
Pg. 1092-8
(Apr 15 2013)
ISSN: 1943-569X [Electronic] United States |
PMID | 23547672
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Drug Combinations
- Insecticides
- Macrolides
- Tablets
- Ivermectin
- selamectin
- spinosad
|
Topics |
- Animals
- Cat Diseases
(drug therapy)
- Cats
- Drug Combinations
- Ectoparasitic Infestations
(drug therapy, veterinary)
- Female
- Insecticides
(administration & dosage, therapeutic use)
- Ivermectin
(administration & dosage, analogs & derivatives, therapeutic use)
- Macrolides
(administration & dosage, therapeutic use)
- Male
- Siphonaptera
(drug effects)
- Tablets
|