A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies.

Abstract

BACKGROUND:

This phase I study investigated the maximum tolerated dose (MTD), safety, pharmacokinetics and antitumor activity of ganetespib in patients with solid malignancies.

METHODS:

Patients were enrolled in cohorts of escalating ganetespib doses, given as 1 hour IV infusion, once weekly for 3 weeks, followed by a 1-week rest until disease progression or unacceptable toxicity. Endpoints included safety, pharmacokinetic and pharmacodynamic parameters and preliminary clinical activity.

RESULTS:

Fifty-three patients were treated at doses escalating from 7 to 259 mg/m(2). The most common adverse events were Grade 1 and 2 diarrhea, fatigue, nausea or vomiting. Dose-limiting toxicities (DLT) observed were: one Grade 3 amylase elevation (150 mg/m(2)), one Grade 3 diarrhea and one Grade 3 and one Grade 4 asthenia (259 mg/m(2)). The MTD was 216 mg/m(2) and the recommended phase 2 dose was established at 200 mg/m(2) given IV at Days 1, 8, and 15 every 4 weeks. There was a linear relationship between dose and exposure. Plasma HSP70 protein levels remained elevated for over a week post treatment. Disease control rate (objective response and stable disease at ≥ 16 weeks) was 24.4%.

CONCLUSIONS:

Ganetespib is well tolerated as a weekly infusion for 3 of every 4 weeks cycle. The recommended phase II dose is 200 mg/m(2), and is associated with an acceptable tolerability profile.

TRIAL REGISTRATION:

NCT00687934.

• Authors: Jonathan W Goldman, Robert N Raju, Gregory A Gordon, Iman El-Hariry, Florentina Teofilivici, Vojo M Vukovic, Robert Bradley, Michael D Karol, Yu Chen, Wei Guo, Takayo Inoue, Lee S Rosen
• Journal: BMC cancer (BMC Cancer) Vol. 13 Pg. 152 (Mar 25 2013) ISSN: 1471-2407 [Electronic] England
• PMID: 23530663 (Publication Type: Clinical Trial, Phase I, Journal Article)

Chemical References

• HSP90 Heat-Shock Proteins
• STA 9090
• Triazoles

Topics

• Adult
• Aged
• Aged, 80 and over
• Drug Administration Schedule
• Female
• HSP90 Heat-Shock Proteins (antagonists & inhibitors, blood)
• Humans
• Male
• Maximum Tolerated Dose
• Middle Aged
• Neoplasm Staging
• Neoplasms (drug therapy, metabolism)
• Treatment Outcome
• Triazoles (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)