Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers.

Abstract	Sinonasal undifferentiated carcinoma is a highly aggressive lesion arising in the superior nasal cavity and paranasal sinuses. Differential diagnosis is wide because a range of similar lesions can present at this site. There is increasing evidence that sinonasal undifferentiated carcinoma is a surface (Schneiderian) epithelial-derived malignancy, with or without concurrent neuroendocrine differentiation. Prognosis is poor; recurrence with metastasis to lymph nodes and distant sites is frequent. A combination of radical surgery, chemotherapy and radiotherapy appears to provide the best chance of survival.
Authors	Diana Bell, Ehab Y Hanna
Journal	Expert review of anticancer therapy (Expert Rev Anticancer Ther) Vol. 13 Issue 3 Pg. 285-96 (Mar 2013) ISSN: 1744-8328 [Electronic] England
PMID	23477516 (Publication Type: Journal Article, Review)
Chemical References	Biomarkers, Tumor
Topics	Animals Biomarkers, Tumor (metabolism) Carcinoma (diagnosis, metabolism, pathology, therapy) Diagnosis, Differential Humans Maxillary Sinus Neoplasms (diagnosis, metabolism, pathology, therapy) Prognosis

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