The developing utility of zebrafish models for cognitive enhancers research.

Abstract

Whereas cognitive impairment is a common symptom in multiple brain disorders, predictive and high-throughput animal models of cognition and behavior are becoming increasingly important in the field of translational neuroscience research. In particular, reliable models of the cognitive deficits characteristic of numerous neurobehavioral disorders such as Alzheimer's disease and schizophrenia have become a significant focus of investigation. While rodents have traditionally been used to study cognitive phenotypes, zebrafish (Danio rerio) are gaining popularity as an excellent model to complement current translational neuroscience research. Here we discuss recent advances in pharmacological and genetic approaches using zebrafish models to study cognitive impairments and to discover novel cognitive enhancers and neuroprotective mechanisms.

• Authors: Adam Michael Stewart, Allan V Kalueff
• Journal: Current neuropharmacology (Curr Neuropharmacol) Vol. 10 Issue 3 Pg. 263-71 (Sep 2012) ISSN: 1570-159X [Print] United Arab Emirates
• PMID: 23449968 (Publication Type: Journal Article)