In the healing test of
acetic acid ulcers in rats with limited food-intake-time,
Z-103 given, p.o., at doses of 3 and 10 mg/kg, twice a day, for 14 consecutive days from the day after
acetic acid injection not only reduced the size and depth of the
ulcers, but also promoted the regeneration of the defective mucosa. In the
hydrocortisone-induced relapse test of
acetic acid ulcers in rats with limited food-intake-time,
Z-103 given, p.o., twice a day, at doses of 3 and 10 mg/kg for 20 consecutive days from the 40th day after the
acid injection strongly prevented the exfoliation of the regenerated mucosa.
Cimetidine (100 mg/kg x 2/day, p.o.), like
Z-103, showed a marked relapse-preventive action in addition to the healing-promoting action. However, it was more effective on the healing.
Gefarnate (300 mg/kg x 2/day, p.o.) markedly reduced the size and depth of the
ulcers and strongly prevented the
steroid-induced relapse, but showed no apparent effect on the regeneration of the defective mucosa. These results suggest that
Z-103 may be a new therapeutic agent sharing both healing-promoting and relapse-preventive actions on
gastric ulcers.