Development of poly(butylene succinate) microspheres for delivery of levodopa in the treatment of Parkinson's disease.

Abstract

Parkinson's is a major neurodegenerative disorder that occurs due to loss of dopaminergic neurons in basal ganglia. Conventional therapy includes surgery that involves lot of risk and administration of levodopa which is accompanied by poor bioavailability, short half-life, and side effects. In the present study, poly(butylene succinate) (PBSu) microspheres-based drug delivery system to improve the bioavailability of the drug levodopa was evaluated for the first time. Biodegradable porous and smooth PBSu microspheres were prepared by double emulsion solvent evaporation technique (W/O/W) and the effect of solvent and surfactant was studied. The maximum encapsulation efficiency achieved was 53.93% and 62.28% for porous and smooth microspheres, respectively. In vitro drug release was studied in phosphate buffered saline and simulated CSF buffer of pH 7.4. Initially a burst effect followed by sustained release of drug was obtained for about 32 h and 159 h for porous and smooth microspheres, respectively. The release rate was higher in simulated CSF when compared with PBS, due to higher concentration of sodium ions and cations in simulated CSF.

• Authors: Krithika Mohanraj, Swaminathan Sethuraman, Uma Maheswari Krishnan
• Journal: Journal of biomedical materials research. Part B, Applied biomaterials (J Biomed Mater Res B Appl Biomater) Vol. 101 Issue 5 Pg. 840-7 (Jul 2013) ISSN: 1552-4981 [Electronic] United States
• PMID: 23401377 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Wiley Periodicals, Inc.

Chemical References

• Antiparkinson Agents
• Biocompatible Materials
• Butylene Glycols
• Delayed-Action Preparations
• Polymers
• Solvents
• Surface-Active Agents
• bionole
• Levodopa

Topics

• Antiparkinson Agents (administration & dosage, cerebrospinal fluid)
• Biocompatible Materials (chemistry)
• Biological Availability
• Blood-Brain Barrier
• Butylene Glycols (chemistry)
• Delayed-Action Preparations
• Drug Delivery Systems
• Humans
• Levodopa (administration & dosage, cerebrospinal fluid)
• Materials Testing
• Microscopy, Electron, Scanning
• Microspheres
• Parkinson Disease (cerebrospinal fluid, drug therapy)
• Polymers (chemistry)
• Porosity
• Solvents
• Surface Properties
• Surface-Active Agents