Abstract | BACKGROUND: METHODS: This retrospective study determined pNGAL levels in 60 healthy individuals, 47 patients with nonmetastatic CRC, and 70 patients with metastatic CRC undergoing curative neoplastic resection. Patients were divided into low- and high-pNGAL groups using a median series-based cutoff. RESULTS: The mean ± SD pNGAL in CRC patients (nonmetastatic and metastatic) was 102.3 ± 66.6 (median 91.4). Nonmetastatic CRC and metastatic CRC patients had higher pNGAL than healthy controls (88 ± 64 and 112 ± 67 vs. 0.6 ± 0.3, respectively, both p < 0.0001). Nonmetastatic CRC patients with deeper tumor invasion and metastatic CRC patients with shorter disease-free interval after CRC resection had higher pNGAL. pNGAL levels correlated with neoplastic tissue volume. CRC patients with recurrence had higher pNGAL than those without recurrence (118 ± 64 vs. 88 ± 66, p = 0.013), and high-pNGAL patients had a higher recurrence rate (59.3 vs. 36.2 %, p = 0.016). Median pNGAL-based risk classification had a sensitivity of 62.5 % for predicting neoplastic progression in CRC patients and 74.3 % for predicting neoplastic progression during the first year after metastatic CRC resection. CONCLUSIONS: pNGAL is higher in CRC patients than in the healthy population, which indicates a potential screening role. High-pNGAL levels are associated with higher neoplastic tissue volume, characteristics of neoplastic invasion, and recurrence, showing a prognostic utility mainly in metastatic CRC patients.
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Authors | Josep Martí, Josep Fuster, Anna M Solà, Georgina Hotter, Rafael Molina, Amalia Pelegrina, Joana Ferrer, Ramon Deulofeu, Constantino Fondevila, Juan Carlos García-Valdecasas |
Journal | World journal of surgery
(World J Surg)
Vol. 37
Issue 5
Pg. 1103-9
(May 2013)
ISSN: 1432-2323 [Electronic] United States |
PMID | 23389669
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Acute-Phase Proteins
- Biomarkers, Tumor
- LCN2 protein, human
- Lipocalin-2
- Lipocalins
- Proto-Oncogene Proteins
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Topics |
- Acute-Phase Proteins
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Case-Control Studies
- Colorectal Neoplasms
(blood, mortality, pathology, surgery)
- Female
- Follow-Up Studies
- Humans
- Lipocalin-2
- Lipocalins
(blood)
- Male
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
(blood)
- Preoperative Period
- Proto-Oncogene Proteins
(blood)
- Retrospective Studies
- Survival Analysis
- Treatment Outcome
- Tumor Burden
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