Abstract | BACKGROUND: METHODS: RESULTS: Plasma levels of IgG1 antibodies to HIV Gag (p18, p24, rp55) and Pol-encoded (p32, p51, p66) proteins were higher in HIV controllers. In contrast, IgG1 antibodies to Env proteins were less discriminatory, with only antigp120 levels being higher in controllers. High-level IgG2 antibodies to any Gag protein were most common in HIV controllers not carrying a 'protective' HLA-B allele, particularly HLA-B*57 (P = 0.016). HIV controllers without 'protective' HLA-B alleles also had higher plasma levels of IgG1 antip32 (P = 0.04). NK cell-activating antibodies to gp140 Env protein were higher in elite controllers but did not differentiate HIV controllers with or without 'protective' HLA-B alleles. IgG1 was increased in FcγRIIa-binding immune complexes from noncontrollers. CONCLUSION: We hypothesize that isotype-switched ( IgG2+) antibodies to HIV Gag proteins and possibly IgG1 antip32 may provide alternative or additional immune control mechanisms to HLA-restricted CD8 T-cell responses in HIV controllers.
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Authors | Martyn A French, Rob J Center, Kim M Wilson, Ibrahim Fleyfel, Sonia Fernandez, Anna Schorcht, Ivan Stratov, Marit Kramski, Stephen J Kent, Anthony D Kelleher |
Journal | AIDS (London, England)
(AIDS)
Vol. 27
Issue 4
Pg. 519-28
(Feb 20 2013)
ISSN: 1473-5571 [Electronic] England |
PMID | 23364441
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fc gamma receptor IIA
- Immunoglobulin G
- RNA, Viral
- Receptors, IgG
- gag Gene Products, Human Immunodeficiency Virus
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Topics |
- Adaptive Immunity
(immunology)
- Alleles
- Blotting, Western
- CD8-Positive T-Lymphocytes
(immunology)
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Female
- HIV Seropositivity
(immunology, physiopathology)
- Host-Pathogen Interactions
- Humans
- Immunoglobulin G
(immunology)
- Killer Cells, Natural
(immunology)
- Lymphocyte Activation
(immunology)
- Male
- RNA, Viral
(immunology)
- Receptors, IgG
(immunology)
- Viral Load
- Virus Replication
(immunology)
- gag Gene Products, Human Immunodeficiency Virus
(immunology)
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