Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients.

Abstract

The discoidin domain receptors, DDR1 and DDR2, have been linked with numerous human cancers. We sought to determine expression level and distribution of DDRs in human breast cancer, and investigate prognostic determinates to determine whether levels of DDRs could predict survival. Tumor samples from 122 breast cancer patients were analyzed for relative expression of DDRs. An additional 24 matched tumor and normal tissues were tested for differential expression of DDR1 and DDR2. DDR2 was found to be significantly increased by 6-fold (P = 0.0005) and DDR1 decreased (P = 0.0001) in tumor vs. normal breast tissue. DDR1 expression was not predictive for patient survival; however, DDR2 expression was significantly associated with disease-free (HR = 0.55, 95 % CI = 0.24-0.78, P = 0.026) and overall survival (HR = 0.46, 95 % CI = 0.35-0.84, P = 0.019). Multivariate analysis revealed DDR2 is an independent favorable predictor for prognosis independent of tumor stage, histology, and patient age. The present research provided the first evidence that increased DDR2 mRNA expression in primary human breast cancer might be a powerful, independent predictor of recurrence and outcome.

• Authors: Tingting Ren, Jian Zhang, Jing Zhang, Xinping Liu, Libo Yao
• Journal: Medical oncology (Northwood, London, England) (Med Oncol) Vol. 30 Issue 1 Pg. 397 (Mar 2013) ISSN: 1559-131X [Electronic] United States
• PMID: 23307244 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Receptors, Mitogen
• DDR1 protein, human
• Discoidin Domain Receptor 1
• Discoidin Domain Receptors
• Receptor Protein-Tyrosine Kinases

Topics

• Biomarkers, Tumor (analysis)
• Breast Neoplasms (metabolism, mortality, pathology)
• Discoidin Domain Receptor 1
• Discoidin Domain Receptors
• Disease-Free Survival
• Female
• Humans
• Immunohistochemistry
• Middle Aged
• Neoplasm Staging
• Prognosis
• Proportional Hazards Models
• Real-Time Polymerase Chain Reaction
• Receptor Protein-Tyrosine Kinases (biosynthesis)
• Receptors, Mitogen (biosynthesis)