Synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol analogs incorporating natural amino acids.

Abstract

In the current study, derivatives of 25-hydroxyprotopanaxadiol (25-OH-PPD) were prepared and their in vitro anti-tumor activities were tested on six different human tumor cell lines by standard MTT assay. The results showed that combining an ester group combined with the presence of an amino acid moiety led to a 10-fold improved anti-tumor activity. Compound 1c exhibited the best anti-tumor activity in the in vitro assays. Compounds 2c, 3c, 4c, 5c, 6c and 8b showed better anti-tumor activities compared to the parent compound 25-OH-PPD. The current results may provide useful data for researching and developing new anti-cancer agents.

• Authors: Peng Wang, Xiu-Li Bi, Jing Xu, Hao-Nan Yuan, Hu-Ri Piao, Yu-Qing Zhao
• Journal: Steroids (Steroids) Vol. 78 Issue 2 Pg. 203-9 (Feb 2013) ISSN: 1878-5867 [Electronic] United States
• PMID: 23178255 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• 25-hydroxyprotopanaxadiol
• Amino Acids
• Antineoplastic Agents
• Ginsenosides

Topics

• Amino Acids (chemistry)
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Ginsenosides (chemical synthesis, chemistry, pharmacology)
• Humans