Abstract | AIM: MATERIALS & METHODS: BPA was administered, followed by pulsed FUS, and the boron concentration in the treated brains was quantified by inductively coupled plasma mass spectroscopy. Growth of the firefly luciferase-labeled glioma cells was monitored through noninvasive biophotonic imaging. Finally, the brain tissue was histologically examined after sacrifice. RESULTS: Compared with the nonsonicated tumor group, animals treated with an injection of 500 mg/kg of BPA followed by FUS exhibited not only significantly increased accumulation of the drug at the sonicated tumor site, but also a significantly elevated tumor-to-normal brain drug ratio (p < 0.05). DISCUSSION:
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Authors | Feng-Yi Yang, Yi-Wei Chen, Fong-In Chou, Sang-Hue Yen, Yi-Li Lin, Tai-Tong Wong |
Journal | Future oncology (London, England)
(Future Oncol)
Vol. 8
Issue 10
Pg. 1361-9
(Oct 2012)
ISSN: 1744-8301 [Electronic] England |
PMID | 23130933
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Blood-Brain Barrier
(radiation effects)
- Boron Neutron Capture Therapy
- Brain Neoplasms
(pathology, therapy)
- Drug Delivery Systems
- Glioblastoma
(pathology, therapy)
- Humans
- Phenylalanine
(administration & dosage, analogs & derivatives)
- Rats
- Sound
- Tissue Distribution
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