Perfusion curve f (t) analysis of breast cancer by contrast-enhanced ultrasonography.

Abstract

BACKGROUND:

Imaging the perfusion of contrast media in breast tumors may allow improved diagnosing and treating breast cancer.

PURPOSE:

To compare the perfusion curve f (t) characteristics of contrast-enhanced ultrasonography in benign and malignant breast tumors.

MATERIAL AND METHODS:

Patients with breast tumors (n = 87) were evaluated with contrast-enhanced ultrasonography and the perfusion curve f (t) parameters were calculated using Sonoliver(®) software to compare analysis (tumor) and reference (normal) tissue areas. Differences between breast and breast tumors were assessed.

RESULTS:

Compared to benign tumors, malignant tumors had faster enhancement time and a shorter mean transit time (all P values < 0.05). The intensity of the signal was also greater for malignant compared with benign tumors.

CONCLUSION:

Perfusion curve f (t) parameter measurements can distinguish differences in vascular flow between malignant and benign breast tumors and may provide a new quantitative indicator of breast tumor.

• Authors: Liang Guo, Zhi-Gang Liu, Pei-Hua Han, Quan Yuan, Yu He, Jun Li
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 53 Issue 9 Pg. 981-6 (Nov 01 2012) ISSN: 1600-0455 [Electronic] England
• PMID: 22969089 (Publication Type: Journal Article)

Chemical References

• Contrast Media
• Phospholipids
• contrast agent BR1
• Sulfur Hexafluoride

Topics

• Adult
• Breast Neoplasms (diagnostic imaging)
• Contrast Media
• Diagnosis, Differential
• Female
• Humans
• Middle Aged
• Neovascularization, Pathologic (diagnostic imaging)
• Phospholipids
• Retrospective Studies
• Software
• Statistics, Nonparametric
• Sulfur Hexafluoride
• Ultrasonography, Mammary