Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: KEY RESULTS: CONCLUSIONS AND IMPLICATIONS:
ONO-2506 did not affect traditional convulsive tests but markedly inhibited epileptic phenomena in the genetic epilepsy mouse model. ONO-2506 enhanced release of inhibitory neuro- and gliotransmitters during the resting stage and inhibited tripartite transmission during the hyperactive stage. The results suggest that ONO-2506 is a novel potential glial-targeting antiepileptic drug. LINKED ARTICLE: This article is commented on by Onat, pp. 1086-1087 of this issue. To view this commentary visit http://dx.doi.org/10.1111/bph.12050.
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Authors | Satoshi Yamamura, Masamitsu Hoshikawa, Kato Dai, Hiromitsu Saito, Noboru Suzuki, Osamu Niwa, Motohiro Okada |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 168
Issue 5
Pg. 1088-100
(Mar 2013)
ISSN: 1476-5381 [Electronic] England |
PMID | 22882023
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society. |
Chemical References |
- Anticonvulsants
- Caprylates
- Convulsants
- ONO2506
- Glutamic Acid
- Serine
- gamma-Aminobutyric Acid
- Kynurenic Acid
- Pentylenetetrazole
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Topics |
- Animals
- Anticonvulsants
(pharmacology, therapeutic use)
- Astrocytes
(drug effects, physiology)
- Caprylates
(pharmacology, therapeutic use)
- Cells, Cultured
- Convulsants
- Disease Models, Animal
- Electroshock
- Epilepsy
(drug therapy, etiology, metabolism, physiopathology)
- Glutamic Acid
(metabolism)
- Kynurenic Acid
(metabolism)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Pentylenetetrazole
- Prefrontal Cortex
(drug effects, metabolism)
- Rats
- Rats, Sprague-Dawley
- Serine
(metabolism)
- Synaptic Transmission
- gamma-Aminobutyric Acid
(metabolism)
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