Cytokine-secreting activity of blood eosinophils in pulmonary tuberculosis.

Abstract

Modern immunological studies showed that eosinophilic granulocytes producing the key mediators of cellular and humoral immune response contribute to the common cytokine imbalance developing in tuberculous infection. A significant increase in BCG-induced secretion of IL-2, IL-5, and TNF-α by eosinophils in patients with pulmonary tuberculosis indicated high reserve reactivity of eosinophilic cells realizing their functional potential in regulation of the specific resistance reactions of the microorganism under conditions of M. tuberculosis infection.

• Authors: U V Kolobovnikova, O I Urazova, V V Novitsky, O V Voronkova, I O Naslednikova, K O Mikheeva, M V Ignatov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 153 Issue 3 Pg. 319-22 (Jul 2012) ISSN: 1573-8221 [Electronic] United States
• PMID: 22866301 (Publication Type: Journal Article)

Chemical References

• Cytokines
• Interleukin-2
• Interleukin-5
• Tumor Necrosis Factor-alpha

Topics

• Adolescent
• Adult
• Case-Control Studies
• Cells, Cultured
• Cytokines (metabolism)
• Eosinophils (metabolism)
• Female
• Humans
• Interleukin-2 (metabolism)
• Interleukin-5 (metabolism)
• Male
• Middle Aged
• Tuberculosis, Pulmonary (metabolism)
• Tumor Necrosis Factor-alpha (metabolism)
• Young Adult