Abstract | UNLABELLED: BACKGROUND: METHODS: A two period, controlled, observer blinded, crossover trial was performed in 12 healthy male subjects. Heme arginate (1 mg/kg body weight) or placebo were infused 24 h prior to a 20 min leg ischemia induced by a thigh cuff. 3 Tesla BOLD-imaging of the calf was performed and signal time courses from soleus, gastrocnemius and tibialis anterior muscle were available from 11 participants for technical reasons. RESULTS: Peak reactive hyperemia signal of the musculature was significantly increased and occurred earlier after heme arginate compared to placebo (106.2 ± 0.6% at 175 ± 16s vs. 104.5 ± 0.6% at 221 ± 19s; p = 0.025 for peak reperfusion and p = 0.012 for time to peak). CONCLUSIONS:
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Authors | Martin Andreas, Albrecht Ingo Schmid, Daniel Doberer, Kiril Schewzow, Stefan Weisshaar, Georg Heinze, Martin Bilban, Ewald Moser, Michael Wolzt |
Journal | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
(J Cardiovasc Magn Reson)
Vol. 14
Pg. 55
(Aug 02 2012)
ISSN: 1532-429X [Electronic] England |
PMID | 22857721
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Heme
- Arginine
- Heme Oxygenase (Decyclizing)
- heme arginate
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Topics |
- Adolescent
- Adult
- Arginine
(administration & dosage)
- Cross-Over Studies
- Follow-Up Studies
- Heme
(administration & dosage)
- Heme Oxygenase (Decyclizing)
- Humans
- Infusions, Intravenous
- Ischemia
(diagnosis, drug therapy, metabolism)
- Leg
(blood supply)
- Magnetic Resonance Imaging
(methods)
- Male
- Muscle, Skeletal
(blood supply, drug effects, metabolism)
- Oxygen Consumption
- Prospective Studies
- Reference Values
- Reperfusion Injury
(diagnosis, metabolism, prevention & control)
- Single-Blind Method
- Treatment Outcome
- Young Adult
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