Present study aims to evaluate the effect of Withania coagulans fruit (aqWC) on diabetic-
dyslipidemia and
antioxidant/
oxidant status in DM. Diabetic animals were treated with aqWC at a dose of 250 mg/kg bw for 30 days.
Lipid profile, MDA, GSH, SOD, FRAP,
HMG CoA reductase and
acetyl CoA carboxylase activities were estimated in blood and tissues. Total
cholesterol, TAG and
LDL were significantly elevated whereas HDL was decreased in diabetic animals (p<0.05), simultaneously the
lipid content and
HMG CoA reductase activities were also increased, whereas
acetyl CoA carboxylase activity decreased significantly in tissues of diabetic animals. MDA was increased and
antioxidants such as SOD, GSH and FRAP decreased significantly in DM (p<0.05).
Oral administration of aqWC to diabetic animals produced significant improvement in serum
lipid profile and tissue
lipid content. Activity of
HMG CoA reductase decreased, whereas
acetyl CoA carboxylase activity increased significantly in tissues after aqWC treatment. Administration of aqWC to diabetic animals also showed significant increase in
antioxidant levels i.e., GSH, SOD, FRAP and reduced level of MDA in blood and tissue homogenates as compared to diabetic controls (p<0.05). These results suggest that aqWC treatment improved
lipid profile and decreased oxidative stress in
diabetes mellitus.