Chemoimmunotherapy as long-term maintenance therapy for cancer.

Abstract

Homeostatic immune regulatory mechanisms can mediate premature termination of therapy-induced antitumor T-effector cell responses. Administration of cyclophosphamide (CY) prior to intratumoral IL-12 and GM-CSF delivery blocked post-treatment T-suppressor cell rebound via elimination of the pre-existing T-suppressor cell pool, allowed repeated activation of antitumor cytotoxic T-cells and resulted in the cure of advanced spontaneous tumors.

• Authors: Nejat K Egilmez, Jamie L Harden, Rachael B Rowswell-Turner
• Journal: Oncoimmunology (Oncoimmunology) Vol. 1 Issue 4 Pg. 563-565 (Jul 01 2012) ISSN: 2162-4011 [Print] United States
• PMID: 22754788 (Publication Type: Journal Article)