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VEGF-D(ilated) lymphatics as gateways to metastasis.

Abstract
VEGF-C and VEGF-D have been implicated in lymphatic metastasis, mainly as inducers of new intra/peritumoral capillary lymphatics. In this issue of Cancer Cell, Karnezis and colleagues challenge this notion and demonstrate that tumor-derived VEGF-D promotes metastasis by causing prostaglandin-dependent dilation of collecting lymphatics outside of the tumor mass.
AuthorsJanusz Rak
JournalCancer cell (Cancer Cell) Vol. 21 Issue 2 Pg. 139-40 (Feb 14 2012) ISSN: 1878-3686 [Electronic] United States
PMID22340584 (Publication Type: Comment, Journal Article)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.

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