Abstract | OBJECTIVE: While aprepitant is actually recommended for the prevention of nausea and vomiting induced by a single cisplatin administration, it is still unclear whether it has a clinical benefit when administered along with daily administrations of low- dose cisplatin(20mg/m2 days 1-5). This study was conducted to evaluate the efficacy of aprepitant in patients receiving daily administration of low-dose cisplatin. METHODS: Our study focused on 25 patients who received cancer therapy including cisplatin, with or without aprepitant (days 1-5). We performed a retrospective study to identify any significant positive effect of aprepitant in the prevention of nausea and vomiting for 10 days(days 1-10). Because cisplatin has a long half-life, we assessed the delayed phase nausea and vomiting(days 6-10). RESULTS AND CONCLUSION: Multiple-day dosing of aprepitant was effective for prevention of nausea(Odds ratio: 0. 30, p= 0. 0012)and vomiting(Odds ratio: 0. 04, p=0. 0001)throughout the observation. Furthermore, we observed a significant positive effect of aprepitant in the prevention of delayed nausea(Odds ratio: 0. 19, p=0. 0083)and vomiting(Odds ratio: 0. 07, p=0. 0040). These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.
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Authors | Misato Kariya, Kenta Tanaka, Kumiko Matsumoto, Manabu Kume, Hiroo Makimoto, Takeshi Hirano, Hideaki Miyake, Masato Fujisawa, Midori Hirai |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 39
Issue 2
Pg. 245-50
(Feb 2012)
ISSN: 0385-0684 [Print] Japan |
PMID | 22333636
(Publication Type: Journal Article)
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Chemical References |
- Morpholines
- Aprepitant
- Cisplatin
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Topics |
- Adult
- Aprepitant
- Cisplatin
(administration & dosage, adverse effects)
- Female
- Humans
- Male
- Morpholines
(administration & dosage, therapeutic use)
- Nausea
(chemically induced, prevention & control)
- Retrospective Studies
- Vomiting
(chemically induced, prevention & control)
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