Clinical response to chemotherapy in locally advanced breast cancer was not associated with several polymorphisms in detoxification enzymes and DNA repair genes.

Abstract	The main aim of the present study was to investigate the association between several genetic polymorphisms (in glutathione S-transferase members and DNA repair genes) and clinical response to chemotherapy in locally advanced breast cancer. A sequential series of 101 patients were prospectively included in this study. Clinical assessment of treatment was accomplished by comparing initial tumor size with preoperative tumor size using revised RECIST guideline (version 1.1). Clinical response was regarded as a response or no response. There was no difference between non-responders and responders for the prevalence of genotypes of the study polymorphisms.
Authors	Mostafa Saadat, Maryam Khalili, Meysam Nasiri, Mehrdad Rajaei, Shahpour Omidvari, Iraj Saadat
Journal	Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 419 Issue 1 Pg. 117-9 (Mar 02 2012) ISSN: 1090-2104 [Electronic] United States
PMID	22330804 (Publication Type: Journal Article)
Copyright	Copyright © 2012 Elsevier Inc. All rights reserved.
Chemical References	Antigens, Nuclear DNA-Binding Proteins Nuclear Proteins X-ray Repair Cross Complementing Protein 1 GSTZ1 protein, human glutathione S-transferase T1 GSTO1 protein, human Glutathione Transferase glutathione S-transferase M1 DNA-Activated Protein Kinase PRKDC protein, human Xrcc6 protein, human Ku Autoantigen
Topics	Adult Aged Aged, 80 and over Antigens, Nuclear (genetics) Antineoplastic Protocols Breast Neoplasms (drug therapy) DNA Repair (genetics) DNA-Activated Protein Kinase (genetics) DNA-Binding Proteins (genetics) Drug Resistance (genetics) Female Glutathione Transferase (genetics) Humans Inactivation, Metabolic (genetics) Ku Autoantigen Middle Aged Nuclear Proteins (genetics) Polymorphism, Genetic Prospective Studies Treatment Outcome X-ray Repair Cross Complementing Protein 1

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