Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir.
Abstract | BACKGROUND: METHODS: RESULTS: Fifty patients were enrolled (n=24 TDF switch; n=26 uridine); median age 48 years; 54% white; 86% male; limb fat 4,494 g. Baseline characteristics were similar between groups. In the NucleomaxX(®) arm, mtRNA increased (all P<0.001), hsCRP and IL-6 increased (both P=0.02), whereas fat mtDNA decreased without changes in limb fat. In the TDF-switch arm, fat mtDNA and inflammation markers did not change; however, significant increases in mtRNAs (P<0.001), limb fat (409 g; IQR -59-1,155) and CD4(+) T-cell count (P=0.03), and decreases in total and hip BMD (median -3.3%; IQR -5.1-0; P=0.005) were observed. Between-group changes were significant for fat mtDNA, hsCRP, IL-6, limb fat and hip BMD. No correlation was found between changes in limb fat and those of fat mtRNA, inflammation markers or protease inhibitor duration. CONCLUSIONS: In HIV lipoatrophy, NucleomaxX(®) improved mtRNA, but worsened inflammation markers and fat mtDNA without changes in limb fat. Switching from a tNRTI to TDF for 48 weeks increased limb fat and fat mtRNA. Large decreases in total and hip BMD were seen after TDF switch.
ClinicalTrials.gov identifier: NCT00119379.
|
Authors | Grace A McComsey, MaryAnn O'Riordan, Julia Choi, Daniel Libutti, David Rowe, Norma Storer, Danielle Harrill, Mariana Gerschenson |
Journal | Antiviral therapy
(Antivir Ther)
Vol. 17
Issue 2
Pg. 347-53
( 2012)
ISSN: 2040-2058 [Electronic] England |
PMID | 22293126
(Publication Type: Clinical Trial, Phase II, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
|
Chemical References |
- Anti-HIV Agents
- DNA, Mitochondrial
- Organophosphonates
- RNA, Mitochondrial
- Reverse Transcriptase Inhibitors
- RNA
- Tenofovir
- Adenine
- Uridine
|
Topics |
- Adenine
(analogs & derivatives, pharmacology, therapeutic use)
- Adipocytes
(pathology)
- Adipose Tissue
(drug effects, pathology)
- Adult
- Anti-HIV Agents
(therapeutic use)
- Apoptosis
(drug effects)
- Bone Density
- DNA, Mitochondrial
(analysis, genetics)
- Female
- HIV Infections
(drug therapy, virology)
- HIV-Associated Lipodystrophy Syndrome
(drug therapy, virology)
- Humans
- Inflammation
(pathology)
- Male
- Middle Aged
- Mitochondria
(drug effects, metabolism, pathology)
- Organophosphonates
(pharmacology, therapeutic use)
- RNA
(analysis, genetics)
- RNA, Mitochondrial
- Reverse Transcriptase Inhibitors
(adverse effects)
- Tenofovir
- Uridine
(pharmacology, therapeutic use)
- Viral Load
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|