Abstract | OBJECTIVES: METHODS:
Measles, mumps, rubella (MMR) and diphtheria- tetanus toxoid (DT)-specific immunoglobulin G antibody concentrations were compared between 400 patients with JIA and 2176 healthy controls aged 1-19 years. Stored patient samples from the period 1997-2006 were obtained from one Dutch centre for paediatric rheumatology. Healthy control samples had been evaluated previously in a nationwide cohort. Participants had been vaccinated according to the Dutch immunisation programme. Antibody concentrations were measured by ELISA (MMR) or multiplex immunoassay (DT). RESULTS: Corrected for age and the number of vaccinations, lower vaccine-specific geometric mean antibody concentrations (GMC) were found in patients with JIA against mumps, rubella, diphtheria and tetanus (p≤0.001). Measles-specific GMC were higher (p<0.001) compared with healthy controls. The prevalence of protective antibody concentrations was significantly lower in patients for mumps (OR 0.4; 95% CI 0.3 to 0.6), rubella (OR 0.4; 0.3 to 0.7), diphtheria (OR 0.1; 0.06 to 0.2) and tetanus (OR 0.1; 0.05 to 0.3). Seroprotection rates against measles did not differ between patients and healthy controls (OR 1.4; 0.8 to 2.5). Methotrexate and glucocorticosteroid use did not affect pathogen-specific GMC or seroprotection rates. CONCLUSIONS: Patients with JIA had lower antibody concentrations and seroprotection rates than healthy controls against mumps, rubella, diphtheria and tetanus, but not measles. In these patients, regular assessment of antibody concentrations and further research on responses to other (booster) vaccines are warranted.
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Authors | Marloes W Heijstek, Pieter G M van Gageldonk, Guy A M Berbers, Nico M Wulffraat |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 71
Issue 6
Pg. 948-54
(Jun 2012)
ISSN: 1468-2060 [Electronic] England |
PMID | 22172491
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Diphtheria-Tetanus-Pertussis Vaccine
- Glucocorticoids
- Immunosuppressive Agents
- Measles-Mumps-Rubella Vaccine
- Methotrexate
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Topics |
- Adolescent
- Antibodies, Viral
(blood, immunology)
- Arthritis, Juvenile
(drug therapy, epidemiology, immunology)
- Child
- Child, Preschool
- Cross-Sectional Studies
- Diphtheria
(prevention & control)
- Diphtheria-Tetanus-Pertussis Vaccine
(immunology)
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Infant
- Male
- Measles
(prevention & control)
- Measles-Mumps-Rubella Vaccine
(immunology)
- Methotrexate
(therapeutic use)
- Mumps
(prevention & control)
- Netherlands
(epidemiology)
- Retrospective Studies
- Rubella
(prevention & control)
- Seroepidemiologic Studies
- Tetanus
(prevention & control)
- Young Adult
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