HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Role of leptin and its receptors in the pathogenesis of thyroid cancer.

Abstract
Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.
AuthorsShahab Uddin, Azhar R Hussain, Abdul K Siraj, Omar S Khan, Prashant P Bavi, Khawla S Al-Kuraya
JournalInternational journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 4 Issue 7 Pg. 637-43 ( 2011) ISSN: 1936-2625 [Electronic] United States
PMID22076163 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • LEPR protein, human
  • Leptin
  • Receptors, Leptin
Topics
  • Humans
  • Leptin (metabolism)
  • Receptors, Leptin (metabolism)
  • Signal Transduction
  • Thyroid Neoplasms (metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: