Abstract |
Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.
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Authors | Shahab Uddin, Azhar R Hussain, Abdul K Siraj, Omar S Khan, Prashant P Bavi, Khawla S Al-Kuraya |
Journal | International journal of clinical and experimental pathology
(Int J Clin Exp Pathol)
Vol. 4
Issue 7
Pg. 637-43
( 2011)
ISSN: 1936-2625 [Electronic] United States |
PMID | 22076163
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- LEPR protein, human
- Leptin
- Receptors, Leptin
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Topics |
- Humans
- Leptin
(metabolism)
- Receptors, Leptin
(metabolism)
- Signal Transduction
- Thyroid Neoplasms
(metabolism, pathology)
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