Comparison of deoxyribonucleic acid ploidy and nuclear expressed p62 c-myc oncogene in the prognosis of colorectal cancer.

Abstract

A simultaneous flow cytometric assay of the nuclear expressed protein product of the c-myc oncogene p62 and deoxyribonucleic acid (DNA) ploidy in archival paraffin-embedded tumor material was undertaken in 179 patients with colorectal cancer, followed for up to 9 years. DNA ploidy showed a survival advantage for diploid tumors (chi 2(1) = 5.39, p = 0.020) and could be used to further divide patients with Dukes' A tumors (chi 2(1) = 4.87, p = 0.027) and Dukes' C tumors (chi 2(1) = 5.33, p = 0.021). By dividing patients into 2 levels of tumor expression of p62 c-myc, there was a trend for improved survival in patients with low expression (chi 2(1) = 3.65, p = 0.056). A combination of ploidy status and p62 c-myc expression improved upon survival prediction by ploidy alone in providing 3 groups (chi 2(2) = 7.86, p = 0.0197). While these results do not suggest a replacement for the Dukes' staging for prognosis (chi 2(3) = 33.82, p less than 0.00001), they strongly support the concept that enhanced expression of c-myc oncogene is associated with the progression of colorectal cancer.

• Authors: S Rowley, K M Newbold, J Gearty, M R Keighley, I A Donovan, J P Neoptolemos
• Journal: World journal of surgery (World J Surg) 1990 Jul-Aug Vol. 14 Issue 4 Pg. 545-50; discussion 551 ISSN: 0364-2313 [Print] United States
• PMID: 2200214 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Neoplasm
• Proto-Oncogene Proteins
• Proto-Oncogene Proteins c-myc

Topics

• Aged
• Colorectal Neoplasms (genetics, mortality)
• DNA, Neoplasm (analysis)
• Female
• Flow Cytometry
• Humans
• Male
• Ploidies
• Prognosis
• Proto-Oncogene Proteins (analysis)
• Proto-Oncogene Proteins c-myc
• Proto-Oncogenes
• Survival Rate
• Time Factors