Abstract | OBJECTIVES: METHODS: The guidelines for the pharmacological treatment of eating disorders are based on studies published between 1977 and 2010. A search of the literature included: anorexia nervosa bulimia nervosa, eating disorder and binge eating disorder. Many compounds have been studied in the therapy of eating disorders (AN: antidepressants (TCA, SSRIs), antipsychotics, antihistaminics, prokinetic agents, zinc, Lithium, naltrexone, human growth hormone, cannabis, clonidine and tube feeding; BN: antidepressants (TCA, SSRIs, RIMA, NRI, other AD), antiepileptics, odansetron, d- fenfluramine Lithium, naltrexone, methylphenidate and light therapy; BED: antidepressants (TCA, SSRIs, SNRIs, NRI), antiepileptics, baclofen, orlistat, d- fenfluramine, naltrexone). RESULTS: In AN 20 randomized controlled trials (RCT) could be identified. For zinc supplementation there is a grade B evidence for AN. For olanzapine there is a category grade B evidence for weight gain. For the other atypical antipsychotics there is grade C evidence. In BN 36 RCT could be identified. For tricyclic antidepressants a grade A evidence exists with a moderate-risk-benefit ratio. For fluoxetine a category grade A evidence exists with a good risk-benefit ratio. For topiramate a grade 2 recommendation can be made. In BED 26 RCT could be identified. For the SSRI sertraline and the antiepileptic topiramate a grade A evidence exists, with different recommendation grades. CONCLUSIONS: Additional research is needed for the improvement of the treatment of eating disorders. Especially for anorexia nervosa there is a need for further pharmacological treatment strategies.
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Authors | Martin Aigner, Janet Treasure, Walter Kaye, Siegfried Kasper, WFSBP Task Force On Eating Disorders |
Journal | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
(World J Biol Psychiatry)
Vol. 12
Issue 6
Pg. 400-43
(Sep 2011)
ISSN: 1814-1412 [Electronic] England |
PMID | 21961502
(Publication Type: Journal Article, Practice Guideline, Review)
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Copyright | © 2011 Informa Healthcare |
Chemical References |
- Anticonvulsants
- Antidepressive Agents
- Antipsychotic Agents
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Topics |
- Anorexia Nervosa
(drug therapy)
- Anticonvulsants
(therapeutic use)
- Antidepressive Agents
(therapeutic use)
- Antipsychotic Agents
(therapeutic use)
- Binge-Eating Disorder
(drug therapy)
- Bulimia Nervosa
(drug therapy)
- Feeding and Eating Disorders
(classification, complications, drug therapy)
- Humans
- Randomized Controlled Trials as Topic
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