Abstract | BACKGROUND: METHODS: We studied 99 Caucasian schizophrenia patients treated with olanzapine. Psychopathology was measured before and after 6 weeks of treatment. Clinical improvement was quantified as change in Positive and Negative Syndrome Scale (PANSS) total scores and subscores as shown by percentage improvement below the baseline score. The clinical response to antipsychotic treatment was defined as 30% improvement from baseline in PANSS scores. RESULTS: The His/Tyr polymorphism was significantly associated with a percentage improvement in PANSS positive symptom subscore (better response in His/His homozygotes; p<0.05) after treatment with olanzapine. As for the T102C polymorphism, a better response in terms of PANSS positive subscore improvement was observed for C/C homozygotes (p<0.01). A significant association of 5-HT2A genotype distribution of the T102C polymorphism with a categorical measure of response, but only in terms of PANSS positive symptom subscores, was observed (p<0.01). CONCLUSIONS:
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Authors | Luiza Olajossy-Hilkesberger, Beata Godlewska, Alexandra Schosser-Haupt, Marcin Olajossy, Jacek Wojcierowski, Jerzy Landowski, Halina Marmurowska-Michałowska, Siegfried Kasper |
Journal | Neuropsychobiology
(Neuropsychobiology)
Vol. 64
Issue 4
Pg. 202-10
( 2011)
ISSN: 1423-0224 [Electronic] Switzerland |
PMID | 21912188
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 S. Karger AG, Basel. |
Chemical References |
- Antipsychotic Agents
- Receptor, Serotonin, 5-HT2A
- Benzodiazepines
- Olanzapine
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Topics |
- Adolescent
- Adult
- Aged
- Antipsychotic Agents
(therapeutic use)
- Benzodiazepines
(therapeutic use)
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Middle Aged
- Olanzapine
- Polymorphism, Single Nucleotide
(genetics)
- Psychiatric Status Rating Scales
(statistics & numerical data)
- Receptor, Serotonin, 5-HT2A
(genetics)
- Schizophrenia, Paranoid
(drug therapy, genetics)
- Sex Characteristics
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