Abstract | BACKGROUND: AIM: MATERIALS AND METHODS: In an open-label study, 21 patients with DSM-IV MDD without psychotic features who had failed to respond to an adequate trial of at least 2 antidepressants were given rTMS therapy for 4 weeks keeping the dose of pre-existing antidepressants unchanged. High-frequency (10 Hz) stimulations were delivered over left dorsolateral prefrontal cortex at an intensity of 110% of the patient's motor threshold. Treatment response was defined as a reduction in score on the Hamilton Rating Scale for Depression (HAM-D) from baseline to end of treatment. Secondary efficacy measures included scores on the Clinical Global Impressions-Change and -Severity scales. RESULTS: At the end of 4 weeks, 19 patients completed the 4 weeks study and were assessed. In ITT analysis the mean HAM-D17 scores were reduced from 30.80±5.00 to 19.00±6.37 (t=8.27, P<0.001). Only 4 patients reported headache but there was no discontinuation due to adverse effects. CONCLUSIONS:
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Authors | Venu Gopal Jhanwar, Ram Jeevan Bishnoi, Lakshman Singh, M R Jhanwar |
Journal | Indian journal of psychiatry
(Indian J Psychiatry)
Vol. 53
Issue 2
Pg. 145-8
(Apr 2011)
ISSN: 1998-3794 [Electronic] India |
PMID | 21772647
(Publication Type: Journal Article)
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