Lack of association between CD58 genetic variations and aspirin-exacerbated respiratory disease in a Korean population.

Abstract

BACKGROUND:

Exacerbation of asthma symptoms due to aspirin ingestion may lead to life-threatening lung failure. The adhesion molecule CD58 gene may play a crucial role in aspirin-exacerbated respiratory disease (AERD) pathogenesis by mediating the biological functions of asthma-inducing mechanisms including T helper cells, proinflammatory cytokines, and natural killer T cells.

OBJECTIVE:

This study aimed to investigate the association of CD58 variations with aspirin-induced bronchospasm in Korean asthma patients.

METHODS:

Seven single-nucleotide polymorphisms were selected for genotyping based on previously reported polymorphisms in the International HapMap database. Genotyping was carried out using TaqMan assay and 2 major haplotypes were obtained in 163 AERD cases and 429 aspirin-tolerant asthma controls. Frequency distributions of CD58 variations were analyzed using logistic and regression models.

RESULTS:

Results showed that none of the analyzed CD58 single-nucleotide polymorphisms and haplotypes was significantly associated with AERD development and fall rate of FEV(1) by aspirin provocation, an important diagnostic marker of aspirin hypersensitivity.

CONCLUSIONS:

This preliminary study suggests that CD58 does not affect AERD susceptibility in a Korean population, and may provide a new direction for future disease etiology.

• Authors: Charisse Flerida A Pasaje, Joon Seol Bae, Byung-Lae Park, Hyun Sub Cheong, An-Soo Jang, Soo-Taek Uh, Mi-Kyeong Kim, Jeong-Hyun Kim, Tae-Joon Park, Jin-Sol Lee, Yongha Kim, Choon-Sik Park, Hyoung Doo Shin
• Journal: The Journal of asthma : official journal of the Association for the Care of Asthma (J Asthma) Vol. 48 Issue 6 Pg. 539-45 (Aug 2011) ISSN: 1532-4303 [Electronic] England
• PMID: 21726122 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CD58 Antigens
• Methacholine Chloride
• Aspirin

Topics

• Adolescent
• Adult
• Aged
• Asian People (genetics)
• Aspirin (pharmacology)
• Asthma, Aspirin-Induced (complications, genetics, physiopathology)
• Body Mass Index
• Bronchial Provocation Tests
• CD58 Antigens (genetics)
• Female
• Forced Expiratory Volume (drug effects, physiology)
• Gene Frequency (genetics)
• Haplotypes (genetics)
• Humans
• Introns (genetics)
• Male
• Methacholine Chloride (pharmacology)
• Middle Aged
• Nasal Polyps (complications)
• Polymorphism, Single Nucleotide (genetics)
• Promoter Regions, Genetic (genetics)
• Republic of Korea
• Smoking (epidemiology)
• Young Adult