Abstract | OBJECTIVE:
Inflammation plays an important role in lung carcinogenesis. Epidemiologic studies have reported inverse associations of non-steroidal anti-inflammatory drug ( NSAID) use and lung cancer risk. Previously, we found that ever use of glucosamine and chondroitin, which have anti-inflammatory properties, were inversely associated with lung cancer risk. After an additional year of follow-up, we further examined the association including frequency/duration of use, interaction with factors associated with inflammation, and lung cancer histology. METHODS: Participants were members of the VITamins And Lifestyle cohort. Adults, aged 50-76 years, who were residents of western Washington State, completed a baseline questionnaire in 2000-2002 (n = 76,904). Participants were queried on their use of glucosamine and chondroitin, over the 10 years prior to baseline, and categorized as nonuser, low use < 4 days/week or < 3 years, or high use ≥ 4 days/week and ≥ 3 years. Lung cancer cases (n = 808) were ascertained through linkage to the Surveillance, Epidemiology, and End Results cancer registry. RESULTS: High 10-year use of glucosamine [hazard ratio (HR), 0.77; 95% CI: 0.56-1.07; p trend = 0.04] but not chondroitin was associated with a reduction in lung cancer risk. The association with glucosamine was limited to adenocarcinoma (HR, 0.49; 95% CI: 0.27-0.90; p trend <0.01) and was not modified by NSAID use or smoking status. CONCLUSIONS:
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Authors | Theodore M Brasky, Johanna W Lampe, Christopher G Slatore, Emily White |
Journal | Cancer causes & control : CCC
(Cancer Causes Control)
Vol. 22
Issue 9
Pg. 1333-42
(Sep 2011)
ISSN: 1573-7225 [Electronic] Netherlands |
PMID | 21706174
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Chondroitin
- Glucosamine
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Topics |
- Adenocarcinoma
(epidemiology, prevention & control)
- Adenocarcinoma of Lung
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Chemoprevention
- Chondroitin
(administration & dosage)
- Cohort Studies
- Female
- Follow-Up Studies
- Glucosamine
(administration & dosage)
- Humans
- Life Style
- Lung Neoplasms
(epidemiology, prevention & control)
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Smoking
(adverse effects)
- Surveys and Questionnaires
- Washington
(epidemiology)
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