Abstract | PURPOSE: METHODS: RESULTS: Rats treated with AraC and 0% DHLHZn cream exhibited complete hair loss; however, treatment with 0.5% or 1% DHLHZn significantly reduced chemotherapy-induced hair loss. Histological analysis revealed that AraC treatment promoted inflammatory cell infiltration of the hair follicles, but this inflammatory response was attenuated by DHLHZn. CONCLUSIONS:
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Authors | Satoshi Hagiwara, Tomohisa Uchida, Hironori Koga, Masafumi Inomata, Fumitaka Yoshizumi, Masatsugu Moriyama, Seigo Kitano, Takayuki Noguchi |
Journal | Surgery today
(Surg Today)
Vol. 41
Issue 5
Pg. 693-7
(May 2011)
ISSN: 1436-2813 [Electronic] Japan |
PMID | 21533943
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Antioxidants
- Ointments
- dihydrolipoylhistidine
- Cytarabine
- Histidine
- Thioctic Acid
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Topics |
- Administration, Topical
- Alopecia
(chemically induced, prevention & control)
- Animals
- Antineoplastic Agents
(adverse effects)
- Antioxidants
(administration & dosage)
- Cytarabine
(adverse effects)
- Hair Follicle
(drug effects)
- Histidine
(administration & dosage, analogs & derivatives)
- Microscopy, Electron, Transmission
- Ointments
- Rats
- Rats, Wistar
- Scalp
(drug effects, pathology)
- Thioctic Acid
(administration & dosage, analogs & derivatives)
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