Alteration of the β-catenin pathway in spiradenoma.

Abstract

BACKGROUND:

Although skin carcinogenesis has been widely investigated, only limited information is available for epidermal tumors, while even less is known about other skin structures. Alterations in the β-catenin pathway have been reported in several epidermal tumors, while little is known about in adnexal tumors. This study was performed to assess alterations in the β-catenin pathway associated with adnexal tumors, and to investigate the mechanisms underlying these alterations.

METHODS:

β-Catenin expression in 48 adnexal tumors (trichoepithelioma, trichofolliculoma, pilomatricoma, syringoma, eccrine poroma, spiradenoma, sebaceous hyperplasia and nevus sebaceus) was assessed using immunohistochemistry. The tumors showing intense nuclear reactivity for β-catenin were further evaluated by immunohistochemistry for β-catenin degradation complex such as adenomatosis polyposis coli (APC), Axin and glycogen synthase kinase 3β (GSK-3β).

RESULTS:

Intense nuclear immunoreactivity for β-catenin was observed in pilomatricoma and spiradenoma. Among 12 eccrine spiradenomas, APC was downregulated in 2 (16.7%) cases, and Axin and GSK-3β were downregulated in 11 (91.7%) and 10 (83.3%) cases, respectively.

CONCLUSIONS:

This is the first reported analysis of the role of alterations in the β-catenin pathway in spiradenoma. We suggest that downregulation of Axin and GSK-3β in the β-catenin pathway may be an important signaling alteration in the development of spiradenoma.

• Authors: Myung Im, Dae H Kim, Joon S Park, Hyun Chung, Young Lee, Chang D Kim, Young J Seo, Jeung H Lee
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 38 Issue 8 Pg. 657-62 (Aug 2011) ISSN: 1600-0560 [Electronic] United States
• PMID: 21518380 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 John Wiley & Sons A/S.

Chemical References

• APC protein, human
• Adaptor Proteins, Signal Transducing
• Adenomatous Polyposis Coli Protein
• Axin Protein
• Biomarkers, Tumor
• CTNNB1 protein, human
• Repressor Proteins
• beta Catenin
• GSK3B protein, human
• Glycogen Synthase Kinase 3 beta
• Glycogen Synthase Kinase 3

Topics

• Adaptor Proteins, Signal Transducing (metabolism)
• Adenoma, Sweat Gland (metabolism, pathology)
• Adenomatous Polyposis Coli Protein (metabolism)
• Axin Protein
• Biomarkers, Tumor (metabolism)
• Cell Nucleus (metabolism, pathology)
• Down-Regulation
• Glycogen Synthase Kinase 3 (metabolism)
• Glycogen Synthase Kinase 3 beta
• Humans
• Repressor Proteins (metabolism)
• Signal Transduction
• Sweat Gland Neoplasms (metabolism, pathology)
• beta Catenin (metabolism)