Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp.

Abstract

A new hirsutane sesquiterpenoid, hirsutanol E (1), together with the known compounds hirsutanol A (2) and hirsutanol F (3; gloeosteretriol) were obtained from AcOEt extract of the marine fungus Chondrostereum sp., which was isolated from the soft coral Sarcophyton tortuosum. The structures were elucidated mainly on the basis of the NMR, MS, and X-ray single-crystal diffraction data. Hirsutanol A (2) exhibited potent cytotoxic activities against various cancer cell lines.

• Authors: Hou-Jin Li, Wen-Jian Lan, Chi-Keung Lam, Fen Yang, Xiao-Feng Zhu
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 8 Issue 2 Pg. 317-24 (Feb 2011) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 21337504 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.

Chemical References

• Acetates
• Antineoplastic Agents
• Complex Mixtures
• Sesquiterpenes
• ethyl acetate

Topics

• Acetates (chemistry)
• Agaricales (chemistry)
• Animals
• Anthozoa
• Antineoplastic Agents (analysis, chemistry, pharmacology, therapeutic use)
• Aquatic Organisms (chemistry)
• Cell Line, Tumor
• Complex Mixtures (analysis, chemistry)
• Crystallography, X-Ray
• Drug Screening Assays, Antitumor
• Female
• Humans
• Inhibitory Concentration 50
• Magnetic Resonance Spectroscopy
• Models, Molecular
• Neoplasms (drug therapy, metabolism)
• Sesquiterpenes (analysis, chemistry, pharmacology, therapeutic use)
• Structure-Activity Relationship