Abstract | PURPOSE: METHODS: Following Internal Review Board approval and parental informed consent, 100 ASA physical status I-II children (3-9 years old) who were scheduled to undergo general anesthesia for esophageal dilatation procedures were enrolled. The patients were randomly assigned to four groups (n = 25 in each). The premedications in the groups were saline (group P), dexmedetomidine 2.5 μg/kg (group D), 0.5 mg/kg midazolam (group MD), and melatonin 0.1 mg/kg (group ML), given orally. All premedication drugs were given with paracetamol 2-2.5 mg/kg to be easily drinkable 40-45 min before anesthesia induction. Anesthesia was maintained with sevoflurane 2-4%, N(2)O 50% in oxygen. No supplemental analgesic agent was given, and an emergence agitation scale (EAS) was measured on admission to the PACU, then every 5 min, and recorded during the postoperative period: 1, awake and calm, cooperative; 2, crying, requires consoling; 3, irritable/restless, screaming, inconsolable; 4, combative, disoriented, thrashing. Children with an agitation score of 3 or 4 were classified as agitated. RESULTS: There were no significant differences among the four groups demographically. The emergence agitation scale was higher in the placebo group than in the others at 5, 10, and 15 min postoperatively (P < 0.001). EA was similar among group D, group MD, and group ML. CONCLUSION:
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Authors | Dilek Özcengiz, Yasemin Gunes, Ozlem Ozmete |
Journal | Journal of anesthesia
(J Anesth)
Vol. 25
Issue 2
Pg. 184-8
(Apr 2011)
ISSN: 1438-8359 [Electronic] Japan |
PMID | 21327805
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Methyl Ethers
- Sevoflurane
- Dexmedetomidine
- Melatonin
- Midazolam
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Topics |
- Administration, Oral
- Child
- Child, Preschool
- Dexmedetomidine
(administration & dosage, therapeutic use)
- Female
- Humans
- Male
- Melatonin
(administration & dosage, therapeutic use)
- Methyl Ethers
(adverse effects)
- Midazolam
(administration & dosage, therapeutic use)
- Postoperative Complications
(prevention & control)
- Preanesthetic Medication
- Psychomotor Agitation
(prevention & control)
- Sevoflurane
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