Abstract |
A CMB monomer was polymerized on a glass plate with a surface-confined ATRP initiator containing a 2-bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non-specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furthermore, the PCMB brush was ablated and a hollow space with a designed shape could be made to which HEK293 cells (from human embryonic kidney) and Hep G2 (from human hepatoma) cells non-specifically adhered, while no adhesion of these cells to the non-treated area on the brush was observed. The present results clearly indicate the usefulness of ion beam-printed patterns of anti-biofouling zwitterionic polymer brushes in the biomedical field.
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Authors | Hiromi Kitano, Hisatomo Suzuki, Takuya Kondo, Kenta Sasaki, Shintaroh Iwanaga, Makoto Nakamura, Kohji Ohno, Yoshiyuki Saruwatari |
Journal | Macromolecular bioscience
(Macromol Biosci)
Vol. 11
Issue 4
Pg. 557-64
(Apr 08 2011)
ISSN: 1616-5195 [Electronic] Germany |
PMID | 21243650
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Coated Materials, Biocompatible
- Ions
- Polymethacrylic Acids
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Topics |
- Cell Adhesion
- Coated Materials, Biocompatible
(chemistry)
- HEK293 Cells
- Hep G2 Cells
- Humans
- Hydrophobic and Hydrophilic Interactions
- Ions
- Polymethacrylic Acids
(chemistry)
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