Alteration in isoenzyme patterns of serum galactosyltransferase activity in ovarian cancer patients: preliminary results.

Abstract

Isoelectric focusing on agarose gel was used to separate the isoenzymes of serum galactosyltransferase (uridine diphosphogalactose: N-acetylglucosaminyl galactosyltransferase, EC 2.4.1.22) from 8 healthy women, and 11 ovarian cancer patients of whom 4 were in clinical remission. In all cases, we found 7 major peaks with isoelectric points ranging from 4.0-5.4. The most acidic peaks were preferentially elevated in the tumor-bearing patients, particularly the peak with pI 4.44.

• Authors: J P Malas, E Bar, P Gauduchon, F Sichel, J Y Le Talaer
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 44 Issue 6 Pg. 325-31 ( 1990) ISSN: 0753-3322 [Print] France
• PMID: 2121294 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Isoenzymes
• Galactosyltransferases

Topics

• Aged
• Carcinoma (enzymology)
• Female
• Galactosyltransferases (blood, metabolism)
• Humans
• Isoelectric Focusing (methods)
• Isoenzymes (blood, metabolism)
• Middle Aged
• Ovarian Neoplasms (enzymology)