Abstract | CONCLUSION: METHODS: We compared serum IgG4 levels as well as nasal computed tomography (CT) and clinicopathological findings before and after glucocorticoid treatment in 31 patients diagnosed as having IgG4-related disease with nasal manifestations. To evaluate immunohistochemical findings of nasal mucosa, we compared them with IgG4-related CRS and common CRS. RESULTS: All patients had levels of high serum IgG4. Ten of the 31 patients had nasal obstruction, nasal discharge, postnasal discharge, hyposmia, and dull headache. They also demonstrated sinus lesions on radiological findings. After glucocorticoid treatment, serum IgG and IgG4 levels were markedly decreased and along with improvement of the symptoms, nasal sinus CT findings also revealed improvement of the sinus opacification. In immunohistochemical examination, the magnitude of IgG4-positive plasma cell infiltration in common CRS was almost the same as in the IgG4-related CRS group. Therefore, in nasal mucosa immunocytochemical positive staining for IgG4 is not specific for definition of IgG4-related disease.
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Authors | Hideaki Moteki, Masanori Yasuo, Hideaki Hamano, Takeshi Uehara, Shin-ichi Usami |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 131
Issue 5
Pg. 518-26
(May 2011)
ISSN: 1651-2251 [Electronic] England |
PMID | 21162659
(Publication Type: Journal Article)
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Chemical References |
- Glucocorticoids
- Immunoglobulin G
- Prednisolone
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Topics |
- Aged
- Aged, 80 and over
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Immunoglobulin G
(blood)
- Immunohistochemistry
- Male
- Middle Aged
- Mikulicz' Disease
(complications)
- Pancreatitis
(complications)
- Paranasal Sinuses
(pathology)
- Prednisolone
(therapeutic use)
- Rhinitis
(blood, diagnosis, drug therapy, etiology)
- Sinusitis
(blood, diagnosis, drug therapy, etiology)
- Tomography, X-Ray Computed
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